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HONG KONG, SHANGHAI and FLORHAM PARK, N.J., Jan. 14, 2021 — Hutchison China MediTech Limited (“Chi-Med”) (Nasdaq/AIM: HCM) today announces that the final assay of savolitinib in Phase Ib TATTON abstraction Parts B and D will be presented at the accessible basic 2020 Apple Conference on Lung Blight (WCLC 2020), demography abode on January 28-31, 2021, virtually.

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Further capacity of the featured affiche presentation are as follows:

About Savolitinib

Savolitinib is an oral, potent, and awful careful baby atom inhibitor of MET, a receptor tyrosine kinase which has been apparent to action abnormally in abounding types of solid tumors announcement bump growth, angiogenesis, and metastasis. Savolitinib has been advised in over 1,000 patients to date. In analytic studies, it has apparent able analytic adeptness in patients with MET gene alterations in assorted bump types with an adequate assurance profile.

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In 2011, Chi-Med entered into a all-around licensing and collective development and commercialization acceding with AstraZeneca PLC (LSE/STO/NYSE: AZN) for savolitinib. Savolitinib’s all-around development plan includes non-small corpuscle lung blight (“NSCLC”) and branch cancer, and added MET-driven tumors are actuality explored.

Savolitinib development in NSCLC:

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Phase II in MET Exon 14 about-face NSCLC (NCT02897479) – In May 2020, abstracts from an advancing open-label, Phase II allotment abstraction was presented as allotment of the American Society of Analytic Oncology 2020 Basic Scientific Program (“ASCO 2020”). In patients with MET Exon 14 absence about-face NSCLC in the adeptness evaluable population, savolitinib approved a 49.2% cold acknowledgment amount (“ORR”), a 93.4% ache ascendancy amount (DCR) and a 9.6 months acting continuance of acknowledgment (“DoR”). 36% of patients in the abstraction accept pulmonary sarcomatoid blight (PSC), an advancing subtype of NSCLC. Abstracts were not yet complete for DoR, progression-free adaptation (PFS) or all-embracing adaptation (“OS”). Analytic abstracts adumbrated an adequate assurance profile, with a low adverse accident (AE) accompanying discontinuations amount of 14.3%. This abstracts accurate the China new biologic appliance (“NDA”) accepting in May 2020.

SAVANNAH Phase II abstraction of savolitinib in aggregate with Tagrisso® in patients who accept progressed afterward Tagrisso® due to MET accession or overexpression (NCT03778229) – The SAVANNAH abstraction is a single-arm, open-label abstraction in epidermal advance agency receptor (“EGFR”) alteration absolute NSCLC patients with MET amplified/overexpressed tumors afterward progression afterwards analysis with Tagrisso®, an EGFR-tyrosine kinase inhibitor endemic by AstraZeneca.

Savolitinib development in branch cancer:

MET-driven papillary renal corpuscle blight (“RCC”) (NCT03091192) – In May 2020, abstracts from 60 patients in the SAVOIR all-around abstraction of savolitinib monotherapy compared with sunitinib monotherapy in MET-driven papillary RCC was presented at ASCO 2020. Savolitinib approved auspicious activity, including an ORR of 27% against 7% for sunitinib, with no savolitinib responding patients with ache progression at abstracts cut-off, and an auspicious OS hazard arrangement of 0.51 (95% CI: 0.21–1.17; p=0.110) with average not accomplished at abstracts cut-off.

CALYPSO Phase II of savolitinib in aggregate with Imfinzi® PD-L1 inhibitor in RCC (NCT02819596) – The CALYPSO abstraction is an investigator accomplished open-label Phase I/II abstraction of savolitinib in aggregate with Imfinzi®, a PD-L1 antibiotic endemic by AstraZeneca. The abstraction is evaluating the assurance and adeptness of the savolitinib/Imfinzi® aggregate in patients with papillary RCC and bright corpuscle RCC.

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Based on these data, AstraZeneca and Chi-Med are actively evaluating the befalling to advance analytic assignment in papillary RCC for savolitinib.

Savolitinib development in added blight indications:

Savolitinib opportunities are additionally continuing to be explored in assorted added MET-driven bump settings via investigator-initiated studies including belly blight and colorectal cancer.

About Chi-Med

Chi-Med (Nasdaq/AIM: HCM) is an avant-garde biopharmaceutical aggregation committed, over the accomplished twenty years, to the analysis and all-around development of targeted therapies and immunotherapies for the analysis of blight and immunological diseases. It has a portfolio of nine blight biologic candidates currently in analytic studies about the apple and all-encompassing bartering basement in its home bazaar of China. For added information, amuse visit: www.chi-med.com.

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Forward-Looking Statements

This columnist absolution contains advanced statements aural the acceptation of the “safe harbor” accoutrement of the U.S. Private Securities Litigation Reform Act of 1995. These advanced statements reflect Chi-Med’s accepted expectations apropos approaching events, including its expectations apropos the ameliorative abeyant of savolitinib for the analysis of patients with NSCLC, the added analytic development of savolitinib in this and added indications, its expectations as to whether analytic studies of savolitinib would accommodated their primary or accessory endpoints, and its expectations as to the timing of the achievement and the absolution of after-effects from such studies. Advanced statements absorb risks and uncertainties. Such risks and uncertainties include, amid added things, assumptions apropos the capability of its abstracts to abutment NDA approval of savolitinib for the analysis of patients with NSCLC in China, its abeyant to accretion active approvals for savolitinib in added jurisdictions such as the U.S., E.U. or Japan, the assurance contour of savolitinib, the abeyant for savolitinib to become a new accepted of affliction for NSCLC patients, its adeptness to apparatus and complete its added analytic development affairs for savolitinib, its abeyant bartering barrage of savolitinib in China and added jurisdictions, the timing of these events, and the appulse of the COVID-19 communicable on accepted economic, authoritative and political conditions. In addition, as assertive studies await on the use of Tagrisso® and Imfinzi® as aggregate analysis with savolitinib, such risks and uncertainties accommodate assumptions apropos the safety, efficacy, accumulation and connected authoritative approval of Tagrisso® and Imfinzi®. Existing and -to-be investors are cautioned not to abode disproportionate assurance on these advanced statements, which allege alone as of the date hereof. For added altercation of these and added risks, see Chi-Med’s filings with the U.S. Securities and Exchange Commission and on AIM. Chi-Med undertakes no obligation to amend or alter the advice independent in this columnist release, whether as a aftereffect of new information, approaching contest or affairs or otherwise.

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